Abstract Introduction: The failure of testicular descent or cryptorchidism is the most common defect in newborn boys. Cryptorchidism is an established risk factor for infertility and testicular germ cell tumors (TGCT). About 10% of all cases of testicular germ cell tumors (TGCT) occur in men with a history of cryptorchidism. The common type of TGCT in cryptorchid testes is seminoma, believed to be derived from pluripotent prenatal germ cells. We report our series of patients with cryptorchidism presenting with TGCT in this study. Materials & Methods: We retrospectively reviewed our hospital medical records for patients presenting with testicular tumor in an undescended testis. The age, presenting symptoms, examination ndings, blood biochemistry reports, imaging records were examined, and noted. The histopathology reports were reviewed. Treatment records, including operative notes were examined in detail and analyzed. Results: During the study period Jan 2001 to Dec 2015 a total of ve patients presented with testicular tumor in an undescended testis. Mean age of patients at presentation was 38.33±0.95 years (29-47 range). The most common presenting symptom was a painless mass in the groin or lower abdomen.
Conclusions: Very little is known about mechanisms of TGCT tumourigenesis. Painless enlargement of a mass in the groin, or an abdominal mass is the most common mode of presentation in these patients. Pain in the region of the mass remains the second most common symptom. Most of the patients present with a locally advanced or metastatic disease and need to be treated with multimodal treatment options.
Keywords: Undescended testes; testicular tumors; seminoma; orchidopexy; intra-abdominal testis.
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