Introduction: The HPV prevalence in India ranges from 33.6% in the Eastern region to 67% in South India and 15% in Western India. The prevalence of HPV6, HPV11, HPV16, and HPV18 were 13%, 20%, 42%, and 47%, respectively. HPV16 was most common, followed by HPV18 and then cross infection (16 and 18); 41% of patients had multiple HPV infections. Methodology: A total of 50 patients with histo pathologically proven head and neck cancer were enrolled into the study. All the patients were given concurrent chemo irradiation after fulfilling the inclusion / exclusion criteria. Patients were enrolled into the study after basic investigations such as CBP, RFT, histopathology and metastatic workup with chest radiograph and ultrasound of abdomen was performed and found to be within normal limits. Results: Out of 50 patients 15 were positive for HPV (P16) and 35 were negative. Prevalence of HPV in HNSCC was 30%. All HPV positive patients were allotted to Arm A and rest of patients were Arm B. Conclusion: No significant association was found between habits like smoking, alcohol and betel nut chewing and HPV infection.

Keywords: HPV Infection; Head and Neck Cancer; Smoking.