Introduction: The success of Functional Endoscopic Sinus Surgery (FESS) depends on the visual clarity of the surgical field, through the endoscope. Aims: The objective of this double-blind, randomized, controlled study was to determine if a pre-operative dose of Bisoprolol (2.5 mg) would reduce the bleeding during FESS and improve the visualization of the operative field. Methods: Sixty ASA I or II patients, scheduled for FESS were randomized to receive either a Placebo (Group A) or 2.5 mg of Bisoprolol (Group B) 90 min prior to the surgery. All the patients received standard anesthesia and monitoring. The aim was to maintain the mean arterial pressure (MAP) of 60–70 mm Hg, by titrating the dose of Sevoflurane and Fentanyl. Results: The blood loss in Control group was (97 ± 16.75 ml) and in Bisoprolol group was (58.3 ± 13.9 ml). The volume percent of Sevoflurane and the dose of Fentanyl used was significantly lower in those who received Bisoprolol. During the operative period, the MAPs were 92.87 ± 6.39 (Group A) and 78.25 ± 3.5 mm Hg (Group B) and the heart rate was 94.75 ± 3.14 min (Group A) and 67.97 ± 1.84 min (Group B). Conclusion: This clinical trial has demonstrated that administration of a single pre-operative dose of bisoprolol (2.5 mg) can significantly reduce the blood loss during FESS and improve the visualization of the operating field.