Background: This prospective randomised study was done to compare iPACK (local anesthetic infiltration in the interspace between Popliteal Artery and Capsule of Knee) versus LIA (Local Infiltration Analgesia), in combination with ACB (Adductor canal block) for post-operative pain managment in patients undergoing TKR (Total Knee Replacement) surgeries. Methods: 120 patients in the age group of 50 to 70 yrs belonging to ASA I & II posted for TKR were divided into two equal Groups and studied. Both the groups received subarachnoid block as the anesthetic technique followed by Adductor canal block. Group A received iPACK and Group B received LIA. Post-operatively parameters like VAS (Visual Analogue Scale), distance walked and opioid consumption were studied. Results: Demographic profile was comparable in both the groups. Both the groups had optimal post-operative analgesia which was evident with respect to VAS, distance walked and opioid consumption. The mean VAS scores at 24 hrs was 2.85 ± 1.45 and 3.14 ± 1.12 in Group A and Group B respectively. The mean VAS scores at 48 hrs was 3.22 ± 2.32 and 3.8 ± 2.91 in Group A and Group B respectively. The distance walked and opioid consumption were comparable in both the Groups. Conclusion: It is concluded that both iPACK and LIA, in combination with Adductor canal block were equally effective in providing post-operative analgesia in TKR patients.