Context: The availabiliy of rapid, shorter acting anesthetics, analgesics and muscle relaxant drugs has faciltated the recovery process and allowed more extensive procedures to be performed on ambulatory basis.1 Dexmedetomidine is highly selective alpha 2 adrenoreceptor agonist with sympatholytic, sedative, amnestic and analgesic properties. It provides unique consious sedation where patient is easily arousable and analgesia without respiratory depression. Aims: To evaluate recovery profile with Dexmedetomidine in Ambulatory Anesthesia. Settings and Design: 60 female patients posted for Medical termination of pregnancy aged between 20 and 40 years were included in the study, and were randomly divided into two groups, Group M (Midazolam) and Group D (Dexmedetomidine) having 30 patients in each. Methods and Materials: All Group D patients received Inj. Ondansetron, Inj. Dexmedetomidine 0.25 ug/kg I.V. slowly over 10 minutes as infusion with hemodynamic monitoring, Inj. Fentanyl l ug/kg I.V. Induction was done with Inj. Propofol upto a maximum of 2 mg/kg in divided doses, titrated to effect. Dexmedetomidine infusion @ 0.25 ug/kg/hour was continued during the procedure if hemodynamic parameters were stable. Statistical Analysis: The statistical significance of difference was tested using Chi-square test, unpaired ‘t’ test, repeated measures analysis of variance (ANOVA), The entire data was statistically analyzed using Statistical Package for Social Sciences (SPSS ver 11.5, Inc. Chicago) for MS Windows. Results: Group D had better recovery profile than Group M, with Group D having shorter awakening (p-value 0.020). Orientation times of (p - value 0.001). Faster achievement of target Aldrete D (p - value 0.001). and Fastrack scores (p - value 0.001). and a rapid home readiness compared to Group M. Conclusions: Dexmedetomidine infusion in lower doses 0.2–0.3 mcg/kg/hr for short duration procedures can be a good choice in multimodal approach in Ambulatory Anesthesia.