Background: Anesthetics are the agents used to induce sedation and analgesia in patients undergoing surgery. Combination of anesthetics plays major role in the major surgery and affect the various systems in the body. The present study aimed to evaluate the sedative and cardiovascular effects of ropivacaine with dexmedetomidine and clonidine in patients undergoing surgery. Materials and Methods: A total of 70 patients were included in the study. They were divided into two groups. G-A (Ropivacaine (0.75%/15 ml) + Dexmedetomidine (1 mcg/kg) and G-B Ropivacaine (0.75%/15 ml) + Clonidine (1 mcg/kg) were administered during surgery time. Study procedure was explained to all the patients and informed consent was taken. After administration of anesthetics to respective groups sedative and cardiovascular functions were recorded and analyzed. Results: 22 patients had a sedation score of 2 in Group A, whereas 35 patients had a sedation score of 2 in Group-B, 13 in Group A had score 3 at 10 min, No patient had sedation score 3 in Group B at 10 min. No one had sedation score 4 in both the groups, (Table 1). 32 patients, showed sedation score ≥ 2 in Group A compared to Group B where only 20 patients had sedation score ≥ 2 throughout the surgery. No one had a score of 3 in both the groups at the end of the surgery. Significant difference in heart rate was observed at 50 min and 70 min which got lowered in Group B when compared to Group A. No significant difference was noted in blood pressure monitoring and use of rescue drug for hypotension in both the groups. Conclusion: Epidural dexmedetomidine cause better sedation more cardiovascular stability compared to clonidine.