Objectives: The present study was carried out to assess the role of caudal epidural injections of steroid with local anesthtic in the management of chronic low-back pain. Materials and Methods: Fifty patients of chronic low-back pain were included in the study. Epidural injections of steroid with local anesthetic were administered to them via caudal approach. Follow up was scheduled after 1 month, 3 months, and 6 months. Assessment was done by using VAS score and ODI. Results: Fifty patients of chronic low-back pain were included in the study. 31 (62%) patients were male and 19 (38%) were female. Age of the patients ranges from 30 to 70 years with the mean age of 55.21 years. Mean VAS score of the patients before the intervention was 7.91 ± 1.60 which was reduced to 3.87 ± 1.21 at 1 month follow-up, 3.46 ± 1.32 at 3 months follow-up and 4.66 ± 1.56 at 6 months follow-up. Similarly, mean ODI of the patients before the treatment was 53.81 ± 6.12 which was reduced to 33.67 ± 4.89 at the end of 1 month, 32.65 ± 5.11 at the end of 3 month and 28.80 ± 4.71 at the end of 6 month. Conclusion: Caudal epidural injection of steroid with local anesthetic is an effective method for the management of chronic low-back pain in terms of pain relief and functional improvement in both short- and long-term results.