Background: In 1940, Reid and Brace first described the hemodynamic response to laryngoscopy and intubation due to noxious stimuli of the upper airway. To minimize this various drugs have been used. Newer opioids like butorphanol, and dexmedetomidine have significant role to suppress hemodynamic changes during laryngoscopy, intubation and pneumoperitoneum. So we have compared the intravenous butorphanol and dexmedetomidine to reduce stress response during laryngoscopy in laparoscopic cholecystectomy. Materials and Methods: The study was carried on 100 patients of both sex with comparable characteristics and of ASA Grade I and II physical status. Patients were allocated into two groups: Group B inj. Butorphanol 30 μg/kg was given 5 minutes before induction and Group D inj. Dexmedetomidine 1 μg/kg diluted in 10 ml normal saline, was given in 10 minutes by infusion pump. Results: The rise in heart rate and blood pressure was less in Dexmedetomidine group as compared to Butorphanol. Conclusions: Dexmedetomidine is better in attenuating the stress response during laryngoscopy, intubation and pneumoperitoneum as compared to butorphanol.