Background: The sensation of pain is a mechanism to protect an organism from injury. However pain is also an unpleasant experience. The conquest of pain has been considered as a path-breaking achievement in the history of medicine. Lignocaine has been considered as one of the time-tested drug used in regional anesthesia, which helped in the alleviation of pain. The duration and quality of sensory and motor blockade with lignocaine are variable. Several innovations are being tried to overcome this drawback. Therefore, there is a need to evaluate the effect of alkalinizing lignocaine in terms of, time for onset of action, degree and duration of blockade. Methods: This double blind, randomized controlled trial was carried out among 60 patients, aged between 18 and 60 years, of ASA Grade I and II, who underwent surgery of the upper limb over a period of six months. The participants were randomly allocated into control group who received 25 ml of 1% plain lignocaine and study group who received 25 ml of 1% alkalinized lignocaine. Onset time of analgesia and paralysis (complete motor block) were recorded. Duration and quality of sensory and motor blockade were also recorded. Results: The onset of sensory and motor blockade was earlier in study group than the control group (p = 0.001). Similarly the duration of sensory and motor block was significantly increased in the study group when compared to the control group (p = 0.001). The number of participants who had complete analgesia and complete paralysis was significantly higher in study group in comparison to the control group. Conclusion: In this modern era of anesthesia which demands higher degree of comfort, stress-free anesthetic and surgical techniques, alkalinized lignocaine solution goes a long way in advancement of anesthetic care.