Introduction: The study based on that midazolam pre-medication reduces the induction dose and cost of propofol. Aims: To study effect of midazolam pre-medication on induction dose of propofol in adult patients. Methods: A prospective randomized, double blind control study was conducted. Total 60 patients (16–45 years) were divided into 2 groups. Group 1 received 0.05 mg/kg of Midazolam and Group 2 received Normal Saline. We compared the induction dose of propofol in both groups, taking loss of verbal contact as the end point. Additionally, changes in hemodynamic status like blood pressure and heart rate and induction time were studied and compared in both groups. Results: The dose of Propofol required to induce anesthesia in Midazolam group was 1.32 mg/kg and 2.27 mg/kg in the control group. The hemodynamic changes in Midazolam group compared to NS were non-significant. Conclusion: We recommend midazolam when used in combination with propofol reduces the dose of propofol and the time required for induction.