This study aims to identify the predictors of mortality in Swine flu-associated deaths and to formulate protocols and guidelines for the future management of Swine flu patients in case of inter-hospital patient transfer, risk stratification, and optimization of other co-morbid conditions. Design: Retrospective Descriptive Study. Materials and Methods: Patients who were admitted to the hospital from September 2017 to March 2018 and September 2018 to March 2019 were included in the study as two separate groups. The data was retrospectively collected from the Medical Records Department (MRD). Information regarding age/ sex, clinical presentation, laboratory findings, organ failures, arterial blood gas parameters, Chest X-ray, duration of ICU stay, need for mechanical ventilation, and pre-existing co-morbidities was collected. Analysis: Categorical variables were presented in numbers. The data was entered in MS Excel spreadsheet and analysis was done using SPSS version 22.0 by calculating percentages. Conclusion: Old age, presence of co-morbidities, late admission to a tertiary care hospital, inter-hospital transfer, and low Pao2/Fio2 ratio at the time of admission were identified as the key factors for early mortality in H1N1 Influenza patients. Recommendation: Better protocols are to be formulated for the management of Swine flu-positive patients in cases of inter-hospital patient transfer, risk stratification, and optimization of other co-morbid conditions.