Introduction: The supraclavicular brachial plexus block provides anaesthesia of entire upper extremity in most consistent manner. Brachial plexus blockade for upper limb surgeries is advantageous as the effect of drug is limited to the part of the body to be operated upon. Materials and Methods: The present study titled “A comparative study of Ropivacaine + Clonidine with Bupivacaine + Clonidine in supraclavicular brachial plexus block” was carried out at Kamineni Institute of Medical Sciences, Narketpally, Nalgonda District, Telangana State. It was a prospective and randomized study. Sixty patients of age group between 18 and 70 years admitted between August 2018 and November 2018 were selected for the study. These patients were undergoing elective operative procedures for upper limb surgeries (i.e., elbow, forearm and hand surgeries). Exclusion criteria included patient’s refusal, history of bleeding disorders or patients on anticoagulant therapy, peripheral neuropathy, local infection, respiratory disease, or known allergy to local anesthetic drugs. Each patient was visited pre-operatively and the procedure was explained and informed written consent was obtained. Investigations like Hemoglobin, Bleeding time, Clotting time, blood grouping, random blood sugar, blood urea, serum creatinine, bleeding time, clotting time, chest x-ray, ECG were done. Results: The present study was conducted on 60 consenting patients aged between 18 and 70 years. Group RC received 30 ml of 0.5% Ropivacaine + clonidine (30 mcg). Group BC received 30 ml of 0.5% Bupivacaine + clonidine (30 mcg) for brachial plexus block by supraclavicular approach. The minimum age in both groups was 18 years. The maximum age in both groups was 60 years and 65 years respectively. The mean age in group BC were 31.20 ± 12.59 and RC were 32.00 ± 13.17 respectively. There was no significant difference in the age of patients between the Group BC and Group RC. Both groups were similar with respect to age distribution (p > 0.05). Conclusion: From our study, we concluded that addition of Clonidine (2 µg/kg) to 0.5% Ropivacaine in supraclavicular brachial plexus block has advantages compare to bupivacaine with clonidine Faster onset of analgesia, sensory and motor blockade.