Introduction: Carbon dioxide insufflation for pneumoperitoneum causes increase plasma levels of catecholamines and vasopressin which leads to hemodynamic disturbances. These effects are exaggerated by the trendelenburg position and long duration of surgery in robot assisted surgeries. This study was designed to evaluate the effect of Dexmedetomidine and fentanyl on hemodynamics in robot assisted surgeries in trendlenberg position. Methods: After obtaining Ethical committee clearance and patients consent, randomised comparative study on 40 ASA I and II patients, who were randomly allocated to receive either dexmedetomedine or fentanyl intravenous infusion was done. Patients with ASA III & IV, on β blockers, HR<55 bpmin were excluded. Intraoperative Hemodynamics, recovery and emergence was assessed. Students ‘t’ test was used. Results: The study included 40 patients undergoing robotic lower abdominal surgeries requiring steep trendlenberg positions. Dexmedetomedine group of patients showed better intra operative hemodynamics at various time intervals as compared to Fentanyl group of patients.