Introduction: An endotracheal tube always considered to be the gold standard to maintain an airway because of its inherent ability to provide positive pressure ventilation [1,2]. Haemodynamic responses, situations of failed intubation, unable to ventilate and unable to intubate are also a serious concern. With the advent of newer supraglottic airway devices, these drawbacks of tracheal tube are avoided. The Proseal laryngeal mask is a new laryngeal mask device with a cuff modified to improve the seal around glottis and a drainage tube to provide for aspiration of gastric contents. The aim of our study was to compare efficacy and safety of Proseal Laryngeal Mask Airway with portex cuffed endotracheal tube in patients undergoing surgeries under general anaesthesia. Aim and Objectives: To compare efficacy and safety of Proseal Laryngeal Mask Airway with Portex cuffed endotracheal intubation in sixty adult patients undergoing surgeries under general anaesthesia. Results: Both groups were comparable with respect to their demographic characteristics. Time taken for insertion in group P and group E was similar. The study participants where Proseal LMA was used had a statistically significant lower rates of HR, SBP, DBP and MAP, at 1, 3, 5, 10 mins and after removal of device than participants in whom endotracheal tube was used. Side effects were lower in group P than group E. Conclusion: Proseal LMA is suitable and safe alternative to endotracheal tube for airway management.