Background: Parturients are often not prepared for labour analgesia in advance. They demand it when they are already in labour with unbearable pain; many a times an hour or two before the delivery. This study was done to evaluate the efficacy of medicine in analgesia during labour. Objective: To assess the efficacy of intrathecal Buprenorphine as a sole method for analgesia in labour. Methods: Double blind, randomized controlled trial, 30 parturients in active labour were studied. Labour ward, Department of Obstetrics and Gynaecology, Dr. Balabhai Nanavati Hospital, Vile Parle, Mumbai, during 1st January 2006 to 31st December 2006. Epi-info 7 was used for analysis and student t-test was used. Results: There was no significant difference in age, weight, height and gestational age between two groups. (p > 0.05). There was significant change in duration of analgesia in both the groups (p < 0.001). Mean Pulse rate At 0 minutes and 2 minutes p value was < 0.05 – significant when compared in both groups. Conclusion: Addition of buprenorphine to intrathecal fentanyl and bupivacaine provides early onset and prolonged duration of analgesia during labour.