Background: Laparascopic surgery is a routinely performed surgery and it is desirable to have a stable intraoperative haemodynamic states by avoiding hypertension and tachycardia. Aim: The present study has been conducted to compare the beneficial effect of alpha2 adrenergic receptor agoinist dexmedetomidine versus placebo in maintaining the perioperative haemodynamic parameters during laparoscopic cholecystectomy. Materials and Methods: The present Randomized double blind comparative study was conducted in the Department of Anaesthesiology. A total of 60 patients randomly allocated in two groups, to Group D (Dexmedetomidine) & Group P (Placebo) of 30 each undergoing elective laparoscopic cholecystectomy, under GA were studied. The patients recieved preloaded and coded study drug as infusion (Dexmedetomidine 0.5 mcg/kg & NS 10 ml) before induction. Results: Sex, age, and weight were comparable in the two groups. The study drug dexmedetomidine maintained cardiovascular stability during laparoscopic cholecystectomy. Mean arterial pressure and heart rate in Group D (Dexmedetomidine) were significantly less after intubation and throughout the period of pneumoperitoneum. In addition, other drugs requirement in placebo group was found to be considerably high when compared to dexmedetomidine group. Conclusion: Dexmedetomidine improves intraoperative and postoperative haemodynamic stability during laparoscopic surgery without prolongation of recovery. Dexmedetomidine was more effective in attenuating hemodynamic response to intubation and pneumoperitoneum when compared with placebo.