Context: Maintaining hemodynamic stability, reducing pain on injection with Propofol and preventing PONV, in TIVA technique is a contentious subject and there is no perfect method to reduce it. Aims: To compare propofol with ketamine and propofol with butorphanol for total intravenous anesthesia in short surgical procedures. Settings and design: Hospital based study was carried out at SVS Medical College, Mahabubnagar. Methods: Total of 60 patients was studied. They were of either sex and the age ranged from 18-60 years. They had ASA-I & ASA-II grade. Two groups of patients were created randomly. Group K, received PropofolKetamine and Group B, Propofol Butorphanol. Both the groups were induced with Propofol 1.5 mg/kg IV and maintained with Propofol 9 mg/kg/hr IV. Statistical analysis: Chi square test and student’s t test were used. Results: The SBP and DBP fell in both groups of patients after induction. SBP & DBP differed significantly during various intervals in patients who belonged to Group B. Such a significant difference was not found in group K. Pain on injection with Propofol was not attenuated by Butorphanol pre-treatment rather than Ketamine. Post-operative sedation was more in Group B (Propofol-Butorphanol) than in Group K (Propofol –Ketamine). Both the groups were found to be comparable in terms of post operative nausea and vomiting. Conclusion: “Propofol-Ketamine (Group K) combination” has been found to be more effective than the other group of patients who belonged to Group B in terms of stability of the hemodynamic parameters as well as sedation was lesser after surgery.