In spite of arthroscopic surgeries being minimally invasive, they cause significant post-op pain. Intraarticular administration of local anaesthetics with or without adjuvants or opioids alone are known to produce post-op analgesia of varying degrees and duration. The purpose of this study was to compare the effects of intra-articular bupivacaine, neostigmine and fentanyl after arthroscopic surgeries. 45 patients were randomized to receive intra-articular bupivacaine, neostigmine and fentanyl after arthroscopic surgery under spinal anaesthesia. Visual analog pain scores (VAS), duration of analgesia as defined as time for first demand for parenteral analgesics and the total subsequent consumption of analgesics was evaluated. There was significant difference of duration of analgesia between the three groups being estimated from Time Zero to the time when the VAS score was greater than 6 and medication for pain was administered. Duration of analgesia was more prolonged in Group III (Fentanyl) as compared to Group I (Bupivacaine) and Group II (Neostigmine). Also, duration of analgesia in Group I was significantly prolonged as compared to Group II. These changes were statistically highly significant when compared to each other (p<0.05). Among all the groups, no significant side-effects were observed.