Objectives: To evaluate the response of dexmedetomidine and magnesium sulphate for attenuating stress response in laparoscopic abdominal surgeries. Material and methods: Patients of ASA grade I and II aged between 20 and 60 years, either gender and who underwent elective laparoscopic abdominal surgeries were included in the study and divided into two groups, group D (n=52) and group M (n=52). Group D patients received Inj dexmedetomidine 1 µg/kg bolus for 15 min followed by 0.2-0.4 µg/kg /hr infusion and group M patients received inj magnesium sulphate 2g bolus for 15 min followed by 12-15 mg/kg/hr infusion. Intraoperative hemodynamic parameters like Heart rate, mean arterial pressure were recorded and emergence time, extubation time and sedation scores were assessed. Results: Heart rate and Mean arterial pressure were significantly low in group D compared to group M. Recovery time and sedation score was significantly higher in group M compared to group D. Time to reach Aldrete score ≥ 9 was significantly more in group M compared to group D. Conclusion: Dexmedetomidine and Magnesium sulphate attenuated stress response to surgery and pneumoperitoneum. Dexmedetomidine had better hemodynamic stability compared to Magnesium sulphate. Early post operative recovery was found in dexmedetomidine group.