Aim and objectives: This prospective, randomised, single blinded controlled study evaluated and compared the efficacy of Bilateral subcostal USG- guided Transversus Abdominis muscle plane block to the Conventional Port site Infiltration in patients who undergo elective Lap- cholecystectomy in Rajiv Gandhi Government General hospital – Madras medical college. Sixty patients belonging to ASA1 and 2, between 18 to 60 years of either sex, satisfying inclusion criteria were randomised into two groups containing 30 patients each. Group 1– TAP block. Group 2 – Port site infiltration. At the end of surgery USG guided TAP block or port site infiltration were given, before extubation. The block was performed under ultrasound guidance. Results: Two groups were similar with respect to demography. Hemodynamics response was similar without any statistical difference between the two groups. Post operative VAS scoring was significantly low in the TAP block with less amount of recue analgesic requirement. Conclusion: We conclude that bilateral USG guided sub costal Transversus abdominis plane block is a better and more efficient alternative method to conventional port site infiltration in Laparoscopic cholecystectomy to provide analgesia in the postoperative period.