Background: Endotracheal intubation is the standard practice for general anaesthesia inspite of many supraglottic airway devices have arrived. Various drugs have been used till date to attenuate the hemodynamic response to endotracheal intubation. This study compared the effects of intravenous Clonidine (2.5 µg/kg) and Lignocaine (1.5 mg/kg), for attenuation of hemodynamic response in laryngoscopy and endotracheal intubation. Methods: Ninety patients of ASA class I & II were divided into two groups of 45 each. Group L patients received injection Lignocaine and Group C patients received injection Clonidine. Hemodynamic parameters were monitored by using multiparameter monitor before intubation and at 1, 3, 5 and 10 minutes after endotracheal intubation. Results: No significant difference between two groups was observed in terms of hemodynamic parameter including heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure. Pretreatment with injection Clonidine is equally better alternative to lignocaine with similar advantages for blunting the undesirable hemodynamic response associated with laryngoscopy and intubation.