"Sepsis" was characterized as the foundational reaction to infecdon, showed by at least 2 of the conditions recorded above for SIRS. "Serious sepsis" was characterized as sepsis related with organ dysflmction, hypoperfusion, or hypotension. Hypoperfijsion and perfusion abnomialities may incorporate however are not constrained to lactic acidosis, oliguria, or an intense change in mental status. Aim: To Study the N-Acetylcysteine and Vitamin C effect on Oxidative stress in Abdominal sepsis and controle Patients with different weight range. Material and Methods: The present Study was conducted in the intensive care Unit of the the Dept of Anesthesiology, Rajiv Gandhi Institute of Medical Sciences, Kadapa. Conclusion: Along these lines, the sex, age and weight of the patients can impact the dimension of hematological and biochemical markers in patients with sepsis. In any case, since the statistic profile of the patients in our examination was similar between the nominal control and sepsis patients and furthermore between the gatherings, it didn't impact the in general outcome.