Background: There are many advantages of ultrasound guided supraclavicular brachial plexus block over the peripheral nerve stimulator guided supraclavicular brachial plexus block. Ultrasonography allows the operator to visualize the neural structures and the surrounding structures. It also guides the needle under real time visualization and navigates the needle away from the sensitive anatomy like pleura, blood vessels etc. Objective: A Comparative Study between Ultrasound and Peripheral Nerve Stimulator Guided Supraclavicular Brachial Plexus Block in Adult Patients for Elective Upper Limb surgeries. Methodology: A prospective comparative study of 60 Patients who were undergoing upper extremity surgery was carried out in the Department of Anesthesiology, JSS Medical College and Hospital, Mysuru, India during the period of November 2016 to July 2018 to compare the ultrasound and peripheral nerve stimulator guided supraclavicular brachial plexus block in adult patients for elective upper limb orthopedic surgeries. Results: The mean time to administer block was 10.17 ± 1.58 minutes in group-US and 10.67 ± 2.58 minutes in group PNS (p=0.57). Thus, in Group US and Group PNS time taken to administer block was statistically not significant. The total duration of sensory block was 10.12 ± 1.14 hours in group-US and 7.41 ± 0.68 hours in group PNS (p<0.0001). The block was successful in 96.67% of patients in group US and 80% in group PNS, which was statistically significant (p<0.05). Conclusion: It was concluded that the ultrasound guided supraclavicular brachial plexus block is more efficient, accurate and safer than the peripheral nerve stimulator guided brachial plexus block as it is characterized by a shorter time of onset and prolonged duration of sensory and motor block.