Context: To assess the safety and efficacy of tramadol and dexamethasone as an adjuvant in enhancing post-operative analgesic effect of local anaesthetic in supraclavicular brachial plexus block (SCBPB). Aims: To compare the efficacy of tramadol and dexamethasone as adjuvants in SCBPB. Material and method: 40 patients belonging to ASA Class I and II, planned for elective upper limb surgery were randomly allocated in 2 groups of 20 each. They received SCBPB. Group T received 20 ml of 0.5% bupivacaine + 15 ml of 2% lignocaine + tramadol 100 mg while Group D received 20 ml of 0.5% bupivacaine + 15 ml of 2% lignocaine + dexamethasone 8 mg. Onset and duration of sensory and motor block, as well as duration of analgesia was observed. Statistical analysis: Unpaired t-test was used for statistical analysis on IBM Statistical Package for Social Sciences version 21. P-value significant if <0.05. Results: The onset of sensory & motor block was shorter, while duration was significantly prolonged in Group D than Group T. The duration of analgesia in group T was 502.5 ± 49.82 minutes and 989.75 ± 126.2 minutes in group D which was statistically highly significant (p<0.0001). Conclusion: It is concluded that dexamethasone when added to local anaesthetic in SCBPB enhances the onset of sensory, prolongs the duration of sensory and motor block and gives extensive duration of analgesia in the postoperative period with steady haemodynamics.