Introduction: There has been an increasing need to find an easily available, effective and feasible method of reducing the incidence of myalgia. Hence, the purpose of the present study is to evaluate and compare the effect of pretreatment with intravenous lidocaine and intramuscular diclofenac in succinylcholine induced post operative myalgia. Materials & Methods: Patients were divided into three groups of 50 each, based on random number generated by computer software and as per the group pretreatment was given. Pain related to the surgical procedure was treated with IV pethidine in a dose of 1 mg/kg. Severity and intensity of post operative myalgia was assessed by the investigator with a standardized questionnaire 1 hour, 24 hours and 48 hours after surgery. Results: There is no significant difference (p > 0.016) between efficacy of intramuscular diclofenac and the control in reducing the intensity of pain at any of the three time points. There is a significant difference (p < 0.016) between efficacy of intravenous lidocaine and the control in reducing the intensity of pain at all of the three time points. There is a significant difference (p < 0.016) between efficacy of intravenous lidocaine and efficacy of intramuscular diclofenac in reducing the intensity of pain at all of the three time points. Discussion & Conclusion: Intravenous lidocaine is effective in reducing the incidence and intensity of succinycholine induced myalgia. Intramuscular diclofenac compares poorly to lidocaine in reducing the incidence and intensity of succinycholine induced myalgia.