It is reported that, peripherally administered NDMA receptor antagonists are involved in anti-nocieption 15 and anti-inflammatory action [16]. The present study was undertaken to evaluate the ketamine hydrochloride gargling NDMA receptor antagonist to attenuate post operative sore throat response after endotracheal intubation in elective operative procedures under general anaesthesia. In the present study, 100 patients of either sex, ASA grade I and II, 20-45 years age range posted for elective operative procedures under general anaesthesia with endotracheal intubation were studied. These patients were divided into 2 equal groups where group I (control) received 30 ml normal saline gargles 40 seconds 5 minutes prior to induction of anaesthesia and group II received 29 ml normal saline with 1 ml Ketamine hydrochloride 50 mg gargles for 40 seconds 5 minutes prior to induction of anaesthesia. Induction of anaesthesia was carried out with IN. Thiopentone 5 mg/kg and IV Suxamethonium 1 mg/kg for felicitation of intubation. With gentle laryngoscopy endotracheal intubation was done with appropriate size red rubber cuff endotracheal tube after lubrication with normal saline. All patients were monitored intraoperatively as well as postoperatively at regular intervals for haemodynamic changes. Postoperative sore throat was assessed at 0, 4 8, and 24 hours in both groups. It was observed that, at 0 hours (immediate postoperative in recovery), the incidence of postoperative sore throat was about 60% in ketamine group as compared to 90% in control group. Out of 60%, 50% of patients had very mild sore throat and 10% moderate sore throat in ketamine group. At 4 and 8 hours, there were maximum patients with no sore throat and mild sore throat in ketamine group as compared to control group. At 24 hours, the incidence of sore throat was very minimum in ketamine group. In control group, the incidence of mild to moderate was 70-90% far more than ketamine group.