Introduction: Adequate maintenance of airways in patients undergoing surgeries under general anaesthesia was through proper intubation. Succinylcholine was the most opted neuromuscular drug in the past 50 years administered for tracheal intubation. A number of adverse reactions with its use. Aim: To evaluate onset time, tracheal intubation conditions, duration of action and maintenance of anaesthesia using two none depolarizing muscle relaxants vecuronium and rocuronium. Materials and methods: The study population consisted of 50 patients of ASA physical status I and II in the age group 18 to 50 years.The present studies was undertaken to evaluate the neuromuscular and haemodynamic properties of Rocuronium bromide and to compare it with Vecuronium bromide. Of the 50 patients studies, 25 patients received 0.6 mg/kg of Rocuronium bromide for the maintenance of anaesthesia and the other 25 patients received 0.1 mg/kg of Vecuronium bromide. The top-up doses administered were 0.15 mg/kg of Rocuronium and 0.025 mg/kg of Vecuronium. In both the groups, the efficacy of nondepolarizing muscle relaxant was assessed. Results: The onset time was significantly shorter in the Rocuronium group (108.8 seconds /mean±SD was ±28.875) compared to Vecuronium group (188.76 seconds/ mean SD±43.78). The duration of action of first dose was significantly longer in Rocuronium group (31.5 minutes) compared to Vecuronium group (24.5 minutes). The duration of action of top-updoses was similar in both the groups (p>0.05). There was no significant difference in any of the haemodynamic variables (Heart rate, Systolic blood pressure, Diastolic blood pressure and meanarterial pressure) between the two groups. All the patients in both the groups were easily reversible with Neostigmine (0.05 mg/kg) and no adverse reactions were found in any patient. Conclusion: Rocuronium has a significantly rapid onset of action and intermediate duration of action. It is easily reversible and produces no significant cardiovascular changes. It also has a good safety profile. Therefore, inspite of its high cost. Rocuronium appears to be the safest drug, near toideal NMBA for rapid sequence intubation and routine intubation when there is no anticipated difficulty in intubation.