Background and Aim: Shivering is a physiological response to core hypothermia in an attempt to raise the metabolic heat production. Non-pharmacological methods using equipment to maintain normal temperature of the body are effective but expensive and lack practicality, while the pharmacological methods are simple, costeffective and easy to implement. Present study aimed to compare therapeutic efficacy of Dexmedetomidine and Tramadol on post subarachnoid block shivering. Material and Methods: This prospective study was conducted in the department of Anaesthesiology at Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat for the period of one year. Seventy ASA Grades-I & II patients of either gender, aged 17 to 61 years scheduled for elective surgeries under subarachnoid block were randomly allocated to two groups (A and B) after obtaining written informed consent. Results: Time interval from injecting the study drug to cessation of shivering was quite less with Dexmedetomidine (39.90±5.98) than with Tramadol (209.14±25.78 seconds). Insignificant difference was noted between the two groups in relation to dizziness. Incidence of sedation (Grade 2) was 17/30 in group D while it was 4/30 in group T and the difference was highly significant (p= 0.0012). Conclusion: Both Dexmedetomidine and Tramadol can be used for treating post sub-arachnoid block shivering but Dexmedetomidine is more efficacious than Tramadol but should be used cautiously in hemodynamically unstable patient.