Context: Proseal laryngeal mask airway is a supraglottic airway device with an additional drainage tube and a dorsal cuff which provides a better seal and prevents aspiration. Aims: 1) to compare the efficacy of PLMA with standard intubation in patients undergoing laparoscopic cholecystectomy. Methods and Material: After approval from the institutional ethical committee a prospective randomized controlled study was conducted in sixty ASA class 1 and 2 patients. After induction Proseal LMA was introduced in group P and endotracheal tube was introduced in group E. Details of insertion, hemodynamic parameters, and ventilatory performance were recorded. During surgery, oxygenation and ventilation variables were adjusted to maintain SpO2 > 95% and EtCO2< 45 mmHg. Statistical analysis used: Data was analyzed using the computer statistical software system Openness (open source epidemiological statistics for public health). The two-tailed student's t-test for unequal variance was used for intergroup comparisons except where specified. Probability values p < 0.05 were considered significant and p < 0.001 were considered highly significant. Results: There was no failed insertion of devices. The mean time of insertion of Proseal (80+43.56 seconds) was greater than conventional intubation (23+17.71 seconds). The difference was statistically highly significant (p<0.01). There were no statistically significant differences in oxygen saturation (SpO2) or end-tidal carbon dioxide (EtCO2) between the two groups before or during peritoneal insufflation. There was no case of inadequate ventilation, regurgitation, or aspiration recorded. Conclusions: Proseal provides a safe alternative to endotracheal intubation for airway management in patients undergoing laparoscopic cholecystectomy.