Background: Stress response is common in any of the operative or laparoscopic procedure. Anesthetic agents like Dexmedetomidine are roped into, to attenuate these hemodynamic responses and to smoothen the operative and postoperative period. This study evaluates the side effects or complications encountered in patients receiving Dexmedetomidine infusion. Methods: This was a descriptive study done in patients with age group 18-65 years age of either sex undergoing laparoscopic surgery and receiving the Dexmedetomidine infusion. Result: Total of 30 patients were included in the study. The mean + SD age of the patients were 31+13.2 years. Bradycardia and hypotension was present in 10% of patients receiving Dexmedetomidine infusion. Conclusion: Bradycardia and hypotension were most common side effects seen with Dexmedetomidine infusion though were self resolving. Thus it is effective in attenuating haemodynamic response to laryngoscopy, intubation, surgery and pneumoperitoneum without significant complications.