Introduction: Peripheral neural blockade remains a well-accepted component of comprehensive anaesthetic care in adults, but nowadays it is gaining popularity for children also. This study aims toevaluate the onset, duration of action, hemodynamic changes and side effects if any of lignocaine 2% plain at 5 mg/kg, lignocaine 2% with epinephrine at 7 mg/kg and bupivacaine 0.5% at 2 mg/kg in children of age group 5-10 years. Materials and Methods: This was a prospective, randomized and double-blinded clinical trial study. 75 pediatric patients of ASA I/ II age group of 5-10 years of either sex, undergoing upper limb surgeries were distributed equally into three groups and given supraclavicular nerve block. Group L patients received lignocaine 2% plain at 5 mg/ kg, Group LE received lignocaine 2% with epinephrine (1:200000) at 7 mg/kg, and Group Breceived Bupivacaine 0.5% plain at 2 mg/kg body weight. Results: 0.5% plain Bupivacaine prolongs the duration of analgesia more than lignocaine 2% plain and lignocaine 2% with epinephrine 1:200000. There was no statistically significant difference in onset of sensory and motor blockade with lignocaine 2% or lignocaine 2% with epinephrine but it is prolonged with 0.5% bupivacaine. There was no significant occurrence of complication in all 3 groups. Conclusion: Lignocaine with or without epinephrine having the quick onset of action than bupivacaine 0.5% plain 2 mg/ kg is good for supraclavicular brachial plexus block in children but for the longer duration of surgery(>2 hr), bupivacaine remains the best option.