Objectives: To investigate the effect of Magnesium Sulphate on Succinylcholine induced fasciculations during General Anaesthesia & postoperative myalgia. Methods: Double blind randomised clinical trial on patients who were candidates for surgery under general anaesthesia. Patients were selected & divided into two equal groups of Study & controls using block randomisation. Study group received Magnesium Sulphate while Controls received Normal Saline. SPSS 18 was used for statistical analysis. Results: Out of the 100 subjects in the study 49 (49%) were men & 51 (51%) were women (p<0.072). The mean age of the two groups were 37.5±12.2 year & 37.7±12 year (p<0.9). There was significant difference between the two groups in terms of the degree of fasciculations & post operative myalgia (p<0.001). Conclusion: Even low dose of magnesium sulphate can prevent & reduce the degree of succinylcholine induced fasciculation & postoperative myalgia.