Introduction and Aims: Transdermal drug delivery is a simple non-invasive and compliant method. It provides a sustained drug release. The aims of this study was to assess the analgesic requirement of patients under General Anesthesia postoperatively after application of Buprenorphine Transdermal patch preoperatively, to assess added analgesic sparing effect, and to assess anxiety level and post extubation discomfort after surgery. Methods and Materials: In this prospective randomized controlled study sixty adult patients, undergoing elective open surgery under General Anesthesia were randomized into 2 groups: Group C (control group) receiving conventional intravenous analgesics, and Group B (study group) receiving transdermal Buprenorphine patch of 10 mcg/hr. All patients were monitored for vital parameters, VAS, MRSS, rescue analgesic requirement and adverse effects till fifth postoperative day. The data was analysed statistically using ‘t’ test. Results: Number of patients requiring postoperative rescue analgesics was higher in group C. Total number of drug doses given in group C was also higher. Haemodynamic parameters were statistically insignificant in both groups at all time periods. VAS score was significantly less in group B till POD2, after which VAS was less in Group B, though not significant. MRSS scale was higher in Group B throughout postoperative period and at time of emergence. Number of patients having adverse effects was slightly high in group B but comparable in both groups. Conclusion: Transdermal buprenorphine patch is effective for postoperative analgesia for elective abdominal and head neck oral surgeries under General Anesthesia. It can reduce requirement of rescue post operative analgesics over atleast five days and maintain hemodynamic stability without serious complications.