Introduction: Clonidine, the older drug is a selective ­2 adrenergic agonist with some ­1 agonist property. In clinical studies, the addition of clonidine to local anesthetic solutions has shown produce anti­nociception and enhance the effect of local anaesthetics. Methodology: This study was conducted on 80 patients undergoing upper limb surgeries aged between 20 to 60 years under ultrasound guided axillary brachial plexus block at Medical College Hospital. Informed written consent was taken. Results: Statistical analysis of sedation score by Chi­square test showed that the difference in sedation score was significant (P <0.05) at 30 and 60 min. The difference in sedation score at 15 min is not statistically significant though few subjects in both the groups were sedated (P >0.05). Conclusion: In conclusion, when compared to clonidine (1g/kg), dexmedetomidine (1g/kg) has a superior clinical profile as adjuvant to levobupivacaine (0.5%) in axillary brachial plexus block.  

Keywords : Clonidine ; Dexmedetomidine ; Levobupivacaine.