Background: Anaphylaxis due to a colloid plasma expander can occur peri-operatively even though it is uncommon. Case Presentation: This the case report of an intra-operative anaphylaxis due to gelofusine in a 31 year old Caucasian female who underwent emergency lower segment caesarean section. The patient was managed successfully and the procedure was completedly uneventfully. Conclusion: A high index of suspicion, immediate diagnosis and rapid institution of treatment are essential for a safe outcome of such incidents.