Objectives: To know the incidence of neonatal complications following premature rupture of membranes more than 12 hours.To study the incidence of early onset sepsis following premature rupture of membranes more than 12 hours. To know the incidence of mortality among neonates born to mothers with PROM more than 12 hours. To know the incidence of neonatal infection in neonates born to mothers with history of PROM more than 12 hours who have not received antibiotics before labour. Methods: Total 185 neonates born to mother’s with PROM of more than 12 hours were evaluated in this study born in Sangameshwar Teaching Hospital and Basaveshwar General and Teaching Hospital attached to M.R. Medical College, Gulbarga. Clinical features like fever, feeding difficulties and respiratory distress were commonly encountered. Laboratory investigations like total count, band count, toxic granules and baby’s blood culture were used for the diagnosis of sepsis. Results: The present prospective study includes 185 cases of neonates born to mothers with PROM of more than 12 hours duration. The incidence of PROM was 4.12%, Respiratory distress syndrome was the most commonest clinical manifestation 35 (18.91%) followed by septicemia 28 cases (15.14%) and pneumonia 3 cases (1.62%). The incidence of septicemia was 15.14%. Most common organisms isolated in blood culture of neonates were Klebsiella in 13 cases (40.6%), Staphylococcus 10 cases (31.3%), E.coli 6 cases (18.8%) and Pseudomonas 3 cases (9.4%). There was strong correlation between maternal genital flora and bacterial isolates of baby’s blood culture. The incidence of neonatal deaths was 1.08% of 15.14% of early onset septicemic neonates. Conclusion: PROM is a high risk Obstetric condition, active management is needed to enable delivery within 18 hours of PROM and it offers better neonatal outcome

Keywords: Premature rupture of membranes; Early onset septicemia; Pneumonia; Respiratory distress syndrome.