This prospective study was conducted in tertiary care hospital attached to Department of pediatrics, Mahadevappa Rampure Medical college Kalburgi.

Aims: To determine the incidence of post phototherapy rebound hyperbilirubenemia in neonates subjected to phototherapy.

Materials and Methods: All babies with hyperbilirubinemia admitted to nicu were included in the study . A total of 200 neonates among which 122 were males and 78 were females. Repeat serum bilirubin was measured 24 hours after stopping phototherapy.

Statistical analysis: Data entry analysis were done using SPSS.

Results: The general incidence of significant rebound hyperbilirubinemia requiring reinitiation of phototherapy was 9.5%. Birth weight and gestation age has significant impact on rebound hyperbilirubinemia.

Conclusion: it is necessary to measure rebound bilirubin levels after 24 hrs of stoppage of phototherapy in high risk neonates like premature babies, birth weight <2kg.

Keywords: Bilirubin; Phototherapy; Significant Rebound.