Aims and Objectives: The aims and objectives of this study is to evaluate the maternal and foetal morbidity and mortality in cases of PROM with elevated C­reactive protein. Material and Methods: he present study was carried out in the department of Obstetrics and Gynaecology as well as the department of Paediatrics, Katihar Medical College and Hospital, Katihar. A total of 120 cases were selected from Obstetrics OPD and admitted indoor patients of obstetrics ward during the period of October 2012 to September 2014. 100 pregnant women beyond 28 weeks of gestation and with history of leaking per vaginum but not in labour were included in study group. Patients with systemic infection and joint disorder were excluded. Control group included 20 pregnant women beyond 28 weeks of gestation with intact membranes. Proper history, clinical examination and investigations were done in both the groups. Result: Incidence of PROM was found to be 3.33%. C­Reactive Protein was significantly raised in 48% cases. Perinatal morbidity was found in 28% babies, out of which 71.4% mothers had raised serum C­ Reactive Protein. Perinatal mortality was found in 12% cases in which all had raised serum C­Reactive Protein. Puerperal pyrexia was present in 10% cases of which 80% had CRP significantly raised. No maternal mortality occurred. Conclusion: It was found that there is significant increase in maternal and foetal morbidity and mortality in cases of PROM where maternal serum C­Reactive Protein level is raised. 

Keywords: PROM; C­Reactive Protein; Fetal Morbidity.