Background: Febrile seizure is an important cause of hospitalisation and morbidity among toddlers and young infants. Various studies have been undertaken in the past to find the association between febrile seizures and several biochemical parameters such as serum Sodium, serum Albumin etc. Objectives: To study the association between levels of serum sodium, calcium, potassium, glucose, zinc and febrile seizures. Methods: This hospital based case control study included patients aged 6 months to 5 years admitted with fever and seizures at a tertiary care teaching hospital over a period of 6 months. Baseline demographic parameters were collected and serum Sodium, Potassium, Calcium, Zinc and random blood sugar estimation was done. Results: A total of 100 cases and 100 controls were included (boys:girls = 2:1). Mean age of cases was 22.39 months while that of controls was 23.29 months. Mean Serum Sodium, Serum Potassium and Serum Zinc levels were found to be lower among cases which was statistically significant. No significant difference could be found between the two groups with respect to mean Random blood sugar and mean serum Calcium. Conclusions: Serum Sodium, serum Potassium, and serum Zinc levels are significantly lower among children with febrile seizures in comparison to children with fever without convulsion, indicating that deficiency of Sodium, Potassium, and Zinc plays a significant role in the pathogenesis of febrile seizures. There is a significant lack of awareness regarding febrile seizure and intermittent prophylaxis of febrile convulsion among the parents. Serum sodium levels and serum calcium levels are predictors of recurrence of febrile seizures.