The study is conducted for application of multimedia design principle as a cost effective tool for must know cardiac muscle knowledge. First MBBS Students- two groups of 20, theory lecture for group A and theory lecture with animations for group B. In MCQ of 90% of Group B shows good to excellent performance; 65% of Group A gave good to excellent performance. The student’s feedback shows that lecture with the animations received good and excellent remarks. The role of teacher as a source of knowledge and role model cannot be replaced by technology. Whereas Application of multimedia design principle in learning is useful for improvement in understanding, reviewing and self-study.

Keywords: Animations; Learning; Multimedia.