Over the past decades, the application of “negative pressure” has evolved to a cornerstone in the treatment of acute and chronic wounds in almost all specialties. Continuous Intermittent, cyclic are the three types of Negative pressure Wound Therapy (NPWT). The cyclic NPWT system is similar to the intermittent mode in terms of using the same maximal sub atmospheric pressure, but the pressure never reaches zero in the cyclic mode. Cyclic application of “negative pressure” results in a superior local enhancement of cutaneous microcirculation with regards to blood flow and consecutive tissue oxygenation. In this article, cyclic NPWT was compared with other NPWT.