Background: An estimated 4 million patients in India are affected by chronic nonhealing wounds with countless hours spent annually for all aspects of wound care. The aim of the study was to assess the efficacy and safety of Oxum [Superoxidised water] verses Neosporin [Topical triple antibiotic] ointment for Chronic nonhealing wounds which was conducted at Era’s Medical College, Lucknow during the period from 15th November 2017 till 30th March 2018 on 30 patients. Nonhealing chronic wounds form a major health burden contributing to substantial morbidity and cost burden on patients and their families as well as on the health sector. Though several new dressing options are currently available which has revolutionized the management of chronic wounds, Oxum is cost effective to middle class patients. Oxum dressing is safe having soothing effect on wounds without causing irritation, pain and allergy to patients. Methods: Total 30 patients of chronic nonhealing wounds were studied. They were divided in to 2 groups, Group A for Oxum dressings and Group B for Neosporin ointment dressings. Results: The mean age group of patients was 50 years [40 to 60 years]. Male to Female ratio was 1.5:1. The patients were followed up in the surgical outpatient department [OPD] up to 20 days minimum and assessed for wound healing, epitheliazation, reduction in the pus discharge, frequency of dressings, and cosmetic healing. The usage of Oxum dressings was more successful in the treatment of chronic wounds than Neosporin. Therefore Oxum can be concluded as gold standard treatment for chronic nonhealing wounds and it is a novel technological innovation in the therapy of chronic wounds.