Background & Objective: Women in her lifecycle goes through pre, peri and post menopausal phases. During these phases there is a profound change in their quality of life. Quality of life is determined by physical health, psychological health, social relationship and environmental factors.This study aimed to compare effect on Quality of life betwe en premenopausal and postmenopausal women.Methods: 60 women were taken for this study of which 30 women were in the premenopausal and 30 women were in the postmenopausal phase. All subjects were asked to fulfill WHOQOL-BREF questionnaire which evaluated women for physical, psychological, social and environmental well being.Results: The results showed that 30% women’s perception in Premenopausal period about their overall quality of life is very good as compared to just 6.67% of women’s perception in Postmenopausal period. Health satisfaction status is better in premenopausal group where 13.3% of women are satisfied with their health status as compared to just 3.3% in postmenopausal period. The mean score in physical health domain for premenopausal women is 61.4+8.49 as compared to 53.23+9.99 in the postmenopausal period. The Premenopausal (mean score 65.66+9.67) have better psychologicalhealth than postmenopausal women(mean score 58.63+10.68). Also there is better social life and adjusting ability in physical environment during premenopausal period as compared to postmenopausal period.Conclusion: Based on the findings of the study it is concluded that quality of life in premenopausal women is better as compared to postmenopausal women.

Keywords: Premenopause, Posmenopause, Quality of Life.