Introduction: Bronchiolitis is a common lung infection in infants and young children during the winter season. The use of chest physiotherapy may be indicated to reduces duration of oxygen therapy, facilitates the clearance of secretions and airway obstruction. Methodology: A 4-month male child with cough, fever, breathlessness, rapid breathing from last two days was taken for this study. Chest physiotherapy (CPT) was given after nebulization therapy (0.9% saline) and was followed by gentle nasopharyngeal suction for next three days. Subject’s Clinical assessment and measurement was done before and after physiotherapy management for respiratory status by using observation sheets, pulse oximeter, respiratory rate timer, stethoscope and X-ray. Results: The present case report shows significance changes from chest physiotherapy in the natural course of acute viral bronchiolitis by showing improvement in all the parameters like FIO2,SPO2 ,HR,RR,Auscultation finding and X ray finding. Discussion: This study demonstrated that chest physiotherapy with nebulization in bronchiolitis is a safe and effective way of treatment. It reduces severity and number of hospital stay days of the subject. Conclusion: The study results can be considered to be included in the hospital guidelines to encourage physiotherapists in mobilization of secretion in bronchiolitis subjects.