Aims and Objectives: The aim of research is to compare the effectiveness of thoracic versus cervical mobilization on physiological parameter in prehypertensive subjects. Methodology: A sample of 30 prehypertensive subjects were recruited for the study. The subject were randomly divided in to 2 groups Group A (Cervical Mobilization) and Group B (Thoracic mobilization group). Grade III posterior anterior vertebral mobilization, single sitting was given for both the group for 60 sec at each level of spinous process from C2-C7 and T1 to T5. Data collected for pre, post immediate and post 30 min for Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Heaert Rate (HR). Results: Comparing of SBP of thoracic and cervical group at pre mobilization, post immediate mobilization and post 30 min mobilization is significance. Discussion: Results of our study explained that when we compare the systolic blood pressure (SBP) variable for cervical group and thoracic mobilization showed the significant lowering effect. Diastolic blood pressure variable, Heart rate variable did not achieve significant level of mean change between the both groups. Conclusions: So it is concluded that thoracic mobilization is much more impressive in decreasing systolic blood pressure (SBP) with significant change as compare to cervical mobilization. Keywords: SBP,DBP,HR ,Thoracic Mobilization and Cervical mobilization.