This article is aimed to provide an evidence-informed integrative overview on exercise therapy and its influence on quality of life in cancer through a literature search of PubMed. Nine systematic reviews and/ or meta- analyses (cancer=5; breast cancer=2; lung cancer=1; prostate cancer=1) were found including two Cochrane systematic reviews, unanimously demonstrating unidirectional effectiveness for exercise therapy in improving quality of life in people with cancer. This interaction between exercise and quality of life was mediated by a complex intermingled inter-relationship between biological, psychological and social dimensions of health and disease. 

Keywords: Participation restriction; Holistic rehabilitation; Biopsychosocial model; Rehabilitation oncology; Behavioral oncology.