Background: The choice of wound closure after surgery, whether major or minor procedure, has always raised many concerns. One of those concerns is how fast and comfortable will be the recovery. Usage of surgical adhesives, 2-Octyl Cyanoacrylate provides a flexible, water resistant, sealed skin closure. It provides a needle-free method of wound closure, an important consideration because of bloodborne viruses (e.g., HIV). Objectives: To discover the advantages and disadvantages of using 2-Octyl Cyanoacrylate glue for skin closure in comparison with that of suturing. Methodology: A comparative study was done in two groups of patients (with 35 patients each). In both the groups, detailed history was taken preoperatively and routine investigations like haemoglobin, total count, ESR, RBS were done to rule out any acute or chronic infection. Shaving of the parts was done at the same time on previous evening. Injection Cefazolin 1 gm single dose was given intravenously at the time of anaesthesia. In one group, 2-Octyl Cyanoacrylate was used as a method of skin closure. In the 2nd group, skin incision was closed using sutures. Results: The present study proves that the Time taken for skin closure, the Post-operative pain and Cosmetic appearance are significantly better with adhesive glue 2-Octyl Cyanoacrylate than the traditional skin closure by suturing. Conclusion: Skin closure with adhesive glue Octyl Cyanoacrylate is better than the traditional skin suturing. As it forms a flexible, water resistant sealed skin closure and allows patient to shower any time after surgery. It is faster, comfortable and cosmetically better technique for skin closure. It significantly reduces post-operative pain. To conclude, adhesive glue Octyl Cyanoacrylate skin closure is a significantly better technique than traditional skin closure by suturing in clean elective surgeries.

Keywords: Adhesive glue; 2 Octyl Cyanoacrylate; Skin suturing; clean elective surgeries.