Background Acute appendicitis is a common surgical emergency that we have to consider when patients present with pain in right iliac fossa. Though one can come to a conclusive diagnosis of acute appendicitis with history and correlation with clinical signs, the negative appendicectomies have remained considerably high (about 15-30% cases). A number of clinical and laboratory based scoring system have been devised to assist the diagnosis. Most widely used is “Alvarado Score” and equally its modifications ie, Modified Alvarado Score [MAS]. The present study aims to evaluate the usefulness of Appendicitis Inflammatory Response Score [AIRS] system in patients with a provisional diagnosis of appendicitis and to avoid negative appendicectomies. Methods The present study selected 60 consecutive patients who presented to emergency department, Sri Adichunchanagiri Hospital and Research Centre, B.G. Nagara, with suspicion of acute appendicitis between March 2017 and Augest 2017. The variables necessary for evaluation are registered and diagnostic performance of two scores was compared. Results The present study included 60 patients with suspicion of acute appendicitis. The results analyzed shows the rate of negative appendicectomy in MAS score found to be 36.66% and rate of negative appendicectomy in AIR score to be 3.33%. the difference between the score to be 33.33%. Hence, proving it to be a better clinical score, when compared to Alvarado score in decresing the rate of negative appendicitis. Conclusions: This study externally validates  the AIR Score for patients with acute appendicitis. The scoring system has a high discriminating power and outperforms the Alvarado score.

Keywords: Appendicitis Inflammatory Response Score; Acute Appendicitis