In India the DS births occur with a frequency of 1 in 800. Because of medical advances and improvements in overall medical care; the median survival of individuals with DS has increased considerably. This longer life expectancy requires giving the necessary care to the individual with DS over their total longer lifespan and determining factors that aim at better quality of life both for the children and for their parents. As concerns about mortality diminish, causes and consequences of morbidity for these children gain importance ( Horwitz et al 2000). This study was tailored to look at the reasons for hospitalization and mortality which may contribute to increased costs and loss of daily wages to their parents and have significant impact on the quality of life of the care givers.