Drugs resistance in tuberculosis comprisesa. Multi drug resistance tuberculosisWHO defines MDR-TB as the strain which is at least resistant to isoniazid and rifampicin with or without resistant to other anti tubercular drugs.b. Extensively Drugs resistance TB: - Cases of TB that are resistant to almost all second line dragger termed extensively drugs resistantThus a person infected with MDR-TB & XDR-TB will unable to be cured by short course chemo therapy which relies chiefly on these two drug. Primary drug resistance occurs mainly to a single drug and combination of drug lessen the chances of drug resistance. In all countries and specially those where the number of case of TB is rising rapidly because of the association with HIV the development of resistant strain, the development of resistance strain of TB is serious concern. In 2008 about 0.5 million people worldwide are estimated to be infected with strain of drug resistant TB.An accurate picture of drug resistance is not available because few countries not having are available drug resistance surveillance system. It is estimated that primary MDR-TB in India is around 3% .The drug resistance retreatment cases is 12-17%. Although the level of MDR-TB in the country is low in relation to percentage and proportion, it translates in to a large absolute number. The most serious danger MDRTB is that, it is much more difficult to treat even where second line drug are available ,treatment of MDR, TB can take at least two year and the result are poor. The magnitude of the crisis remains to be determined with the dip in the laboratory capabilities for conducting quality assured susceptibility test especially for second line drug